Canine iPS Cell-Derived Platelets have Applications
in Veterinary and Human Medicine

Toshiya Nishimura
Department of Advanced Pathobiology, Graduate School of Life and
Environmental Sciences, Osaka Prefecture University

 

 

 

 

 

Thrombocytopenia (TTP) is a common acquired hemostatic and platelet disorder in canines
and human beings. Currently there is no valid therapy for this disease except blood transfusion. However, blood contribution from donors are limited and other feasible methods should therefore be explored. In order to resolve this issue, we generated “canine induced pluripotent stem cells” (ciPSCs) and created functional platelets from ciPSCs. Using this technology, we can supply platelets to TTP patients sustainably instead of blood transfusion. We believe this technology will lead to new therapy for both human and canine diseases.